Scandium-47 as a radionuclide precursor: Feasibility of production in a 47Ca/47Sc generator-like system
The <sup>47</sup>Ca/<sup>47</sup>Sc quasi-generator system based on neutron irradiation of enriched <sup>46</sup>Ca targets offers a reliable source of high-quality <sup>47</sup>Sc for radiopharmaceutical applications. Multiple elutions from a single target enable sustained production of <sup>47</sup>Sc with excellent radionuclidic and radiochemical purity. These results support further development of <sup>47</sup>Sc as a theranostic radionuclide for larger-scale production. A preliminary specification for <sup>47</sup>Sc as a radionuclide precursor was proposed following the European Pharmacopoeia guidelines, providing a groundwork for future standardisation.
Authors
- Dariusz Pawlak (ORCID: https://orcid.org/0000-0002-0358-0915)
- Renata Mikołajczak (ORCID: https://orcid.org/0000-0002-6882-751X)
- Z. Tymiński (ORCID: https://orcid.org/0000-0001-9977-4150)
- Izabela Cieszykowska (ORCID: https://orcid.org/0000-0003-3052-4852)
- J. Marganiec (ORCID: https://orcid.org/0000-0002-0327-1629)
- Małgorzata Żółtowska (ORCID: https://orcid.org/0000-0002-4880-1574)
- Łukasz Sochaczewski (ORCID: https://orcid.org/0000-0002-9795-6759)
Institutions
- National Centre for Nuclear Research (PL)
Publication Details
- Journal
- Nuclear Medicine and Biology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.nucmedbio.2025.109595
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00