Traditional Use of Medicinal Plants for Symptom Relief During the COVID-19 Pandemic in Bulgaria

The COVID-19 pandemic has renewed global interest in medicinal plants as accessible sources of prophylactic and supportive therapies. Ethnobotanical research provides an important foundation for developing plant-based medicines with preventive and therapeutic potential. This study aimed (1) to investigate the distribution and indications for the use of medicinal plants in the prevention and relief of COVID-19-related symptoms among the Bulgarian population, and (2) to identify culturally significant species with potential for further development as antiviral agents. A total of 513 respondents from different regions and demographic groups in Bulgaria were interviewed. Their knowledge regarding the use of medicinal plants for COVID-19 prevention or treatment was quantitatively assessed using ethnobotanical indices: relative frequency of citation (RFC), informant consensus factor (FIC), fidelity level (FL), and use value (UV). Participants reported 45 species belonging to 43 genera and 23 families. The highest RFC and UVs were recorded for <i>Matricaria chamomilla</i> L., <i>Tilia</i> sp., <i>Thymus vulgaris</i> L., <i>Zingiber officinale</i> Roscoe, <i>Mentha</i> sp., <i>Citrus x limon</i> (L.) Osbeck, <i>Rosa canina</i> L., and <i>Sideritis scardica</i> Griseb. Culturally significant species identified were <i>Thymus vulgaris</i> L., <i>Matricaria chamomilla</i> L., <i>Tilia</i> sp., <i>Mentha</i> sp., <i>Sideritis scardica</i> Griseb, <i>Zingiber officinale</i> Roscoe, and <i>Citrus x limon</i> (L.) Osbeck. This ethnobotanical survey in Bulgaria documents culturally important medicinal plants that may have potential applications in prophylaxis and complementary therapy for COVID-19.