Additive Clinical Utility of Microsatellite Instability and Tumor Mutational Burden to Predict Immune Checkpoint Inhibitor Effectiveness in Metastatic Castration-Resistant Prostate Cancer

These findings add support for tTMB and tMSI in predicting ICI monotherapy benefit in mCRPC and provide evidence supporting bMSI testing when tissue is unavailable.

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Publication Details

Journal
Clinical Cancer Research
Published
2025-12-04
DOI
https://doi.org/10.1158/1078-0432.ccr-25-2750
Primary Topic
Prostate Cancer Treatment and Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Additive Clinical Utility of Microsatellite Instability and Tumor Mutational Burden to Predict Immune Checkpoint Inhibitor Effectiveness in Metastatic Castration-Resistant Prostate Cancer

Ryon P. Graf, Alan Haruo Bryce, Umang Swami, Zeynep İrem Özay et al.
Clinical Cancer Research
Prostate Cancer Treatment and Research
article

Additive Clinical Utility of Microsatellite Instability and Tumor Mutational Burden to Predict Immune Checkpoint Inhibitor Effectiveness in Metastatic Castration-Resistant Prostate Cancer

Ryon P. Graf, Alan Haruo Bryce, Umang Swami, Zeynep İrem Özay, Gerald Li, Douglas I. Lin, Rana R. McKay, Julia A. Elvin, Júlia C.F. Quintanilha, Nicolas Sayegh, Chadi Hage Chehade, Jeffrey S. Ross, Tian Zhang, Neeraj Agarwal
article en

Abstract

These findings add support for tTMB and tMSI in predicting ICI monotherapy benefit in mCRPC and provide evidence supporting bMSI testing when tissue is unavailable.

Clinical Cancer ResearchVol. 32(4)
City Of Hope National Medical Center (US), SUNY Upstate Medical University (US), University of Utah (US), Huntsman Cancer Institute (US), Boston Foundation (US), GlobalFoundries (United States) (US), University of California San Diego (US), AstraZeneca (South Korea) (KR), Southwestern Medical Center (US), City of Hope (US), AstraZeneca (Brazil) (BR), Veterans Medical Research Foundation of San Diego (US), Foundation Medicine (United States), The University of Texas Southwestern Medical Center (US)
Flatiron Health, Foundation Medicine
Openalex Percentile: Top 43%
Prostate Cancer Treatment and Research
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