Additive Clinical Utility of Microsatellite Instability and Tumor Mutational Burden to Predict Immune Checkpoint Inhibitor Effectiveness in Metastatic Castration-Resistant Prostate Cancer
These findings add support for tTMB and tMSI in predicting ICI monotherapy benefit in mCRPC and provide evidence supporting bMSI testing when tissue is unavailable.
Authors
- Ryon P. Graf (ORCID: https://orcid.org/0000-0002-8065-4148)
- Alan Haruo Bryce (ORCID: https://orcid.org/0000-0002-0206-3895)
- Umang Swami (ORCID: https://orcid.org/0000-0003-3518-0411)
- Zeynep İrem Özay (ORCID: https://orcid.org/0000-0002-4827-9042)
- Gerald Li (ORCID: https://orcid.org/0000-0002-5617-6262)
- Douglas I. Lin (ORCID: https://orcid.org/0000-0003-0105-9760)
- Rana R. McKay (ORCID: https://orcid.org/0000-0002-0581-7963)
- Julia A. Elvin (ORCID: https://orcid.org/0000-0001-9476-9563)
- Júlia C.F. Quintanilha (ORCID: https://orcid.org/0000-0001-6908-4474)
- Nicolas Sayegh (ORCID: https://orcid.org/0000-0003-1924-8148)
- Chadi Hage Chehade (ORCID: https://orcid.org/0009-0008-6735-5777)
- Jeffrey S. Ross (ORCID: https://orcid.org/0000-0001-8494-2596)
- Tian Zhang (ORCID: https://orcid.org/0000-0001-8914-3531)
- Neeraj Agarwal (ORCID: https://orcid.org/0000-0003-1076-0428)
Institutions
- City Of Hope National Medical Center (US)
- SUNY Upstate Medical University (US)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- Boston Foundation (US)
- GlobalFoundries (United States) (US)
- University of California San Diego (US)
- AstraZeneca (South Korea) (KR)
- Southwestern Medical Center (US)
- City of Hope (US)
- AstraZeneca (Brazil) (BR)
- Veterans Medical Research Foundation of San Diego (US)
- Foundation Medicine (United States)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2750
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Flatiron Health
- Foundation Medicine