Evaluating Efficacy and Tolerability of a New Intradermal Biorejuvenation with Free Hyaluronic Acid and Glycerol in Photoaging: A Retrospective Pilot Study

Background: Photoaging results from cumulative ultraviolet-induced damage, mainly affecting sun-exposed areas such as the face, neck, and forearms. It manifests with textural roughness, irregular pigmentation, and wrinkles, reflecting structural degeneration across cutaneous layers. Objectives: This retrospective, uncontrolled, pilot study evaluated the efficacy of a biorejuvenating intradermal treatment combining free hyaluronic acid (HA) and glycerol in improving skin quality assessed by VISIA® CR. Secondary objectives included morphological and structural evaluation with PRIMOS 3D and LC-OCT, and exploratory clustering of post-treatment topography. Methods: Seventeen Caucasian women (45–67 years; mean 54, Fitzpatrick I–III) received HA-glycerol (CROMA Revitalis) via three-session picotage (n = 10) or two-session four-point injection (n = 7). VISIA® CR5 (spots, wrinkles, texture, pores, UV spots, porphyrins), PRIMOS 3D (roughness, volumetric parameters), and LC-OCT (stratum corneum and epidermal thickness, DEJ undulation) were analyzed. Results: VISIA® CR5 showed significant reductions in visible spots and porphyrins, with trends toward improvement in wrinkles and UV spots. PRIMOS 3D demonstrated qualitative improvement in most patients, and LC-OCT documented a significant increase in stratum corneum thickness with positive remodeling trends. Conclusions: This retrospective uncontrolled pilot study suggests that HA–glycerol intradermal biorejuvenation may improve multiple markers of photoaging, although conclusions are limited by sample size and short follow-up.