Case Report: Exercise-associated changes of leukocyte gene expression in statin-associated myopathy
This case study suggests that profiling the exercise-induced immune transcriptome can reveal dynamic immunological changes related to statin-induced myopathy. These findings support the hypothesis of an immune-mediated component in SAMS and provide a basis for future studies to validate transcriptomic biomarkers for the early detection and management of SAMS.
Authors
- David Elashoff
- Adrian Hairapetian
- T. Bao (ORCID: https://orcid.org/0000-0002-9071-0916)
- Thomas Vu
- Monica Cappelletti
- Mario C. Deng (ORCID: https://orcid.org/0000-0002-5202-3816)
- Elaine F. Reed (ORCID: https://orcid.org/0000-0002-3524-545X)
- Galyna Bondar
- Jeffrey J. Hsu (ORCID: https://orcid.org/0000-0002-9971-5916)
- Tristan Grogan (ORCID: https://orcid.org/0000-0001-9471-2938)
- Irina Silacheva
- Joshua Chandran
- Ruben Adamov
- Lorenzo Mancusi
- Abhinandan Das Mahapatra (ORCID: https://orcid.org/0000-0002-2039-9309)
- Ananya Katappagari
- Ailing Yang (ORCID: https://orcid.org/0000-0002-4096-044X)
- Anca Rahman
- Liana Galan
- Stephanie Su
- N C Dang
- Pejman Mansouri
- Isabel Lai
- P. Ping
- Ananya Bukkapatnam
- Mahi Mirchandani
Institutions
- Strand Life Sciences (India) (IN)
- University of California, Los Angeles (US)
- Los Angeles Medical Center (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.3389/fphar.2025.1695543
- Primary Topic
- Exercise and Physiological Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health