Ligustrazine attenuates ferroptosis in proximal straight tubule cells via IGF2BP1–Odc1 regulation in a CKD model
Ligustrazine reduced the binding of IGF2BP1 to Odc1 mRNA, downregulated Odc1 protein expression, thereby decreasing ferroptosis, and restoring renal function.
Authors
- Weijian Xiong (ORCID: https://orcid.org/0000-0001-6920-1909)
- Xunjia Li (ORCID: https://orcid.org/0000-0002-1182-2638)
- Deyu Zuo (ORCID: https://orcid.org/0000-0001-6901-1742)
- Chengxuan Liu
- An He (ORCID: https://orcid.org/0000-0002-0990-1193)
- Dingyi Lv (ORCID: https://orcid.org/0000-0001-5635-3559)
- Ying Li (ORCID: https://orcid.org/0000-0002-3868-9021)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1097/js9.0000000000004073
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00