The Influence of Dexmedetomidine Added to Ropivacaine on Its Pharmacokinetic and Pharmacodynamic Effects During Lumbar Plexus Block
Our research demonstrated that dexmedetomidine significantly influences the pharmacokinetics and pharmacodynamics of ropivacaine in LPB. When combining dexmedetomidine 0.5 µg·kg-1 with ropivacaine for LPB in a 66 kg adult, the maximum ropivacaine dose should not exceed 3.7 mg·kg-1.
Authors
- Hua Zhu (ORCID: https://orcid.org/0000-0002-4198-5809)
- Yuqing Chen (ORCID: https://orcid.org/0000-0003-3832-3836)
- Junyan Wu (ORCID: https://orcid.org/0000-0003-0870-382X)
- Jiebin Ou
- Ying Wang (ORCID: https://orcid.org/0000-0001-7808-6279)
- Chen Ye (ORCID: https://orcid.org/0000-0003-3935-1601)
- Hai-Ming Huang
- Xiaoxia Yu
- Zeyuan He
Institutions
- American Association of Colleges of Pharmacy (US)
- University of Pharmacy Mandalay (MM)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1213/ane.0000000000007871
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00