A High-Fiber, Plant-Based Diet in Myeloma Precursor Disorders: Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model
Consumption of a western diet and high body mass index (BMI) are risk factors for progression from pre-malignant phenotypes to multiple myeloma, a hematologic cancer. In the NUTRIVENTION trial (NCT04920084), we administered a high-fiber, plant-based diet (meals for 12 weeks, coaching for 24 weeks) to 23 participants with myeloma precursor states and elevated BMI. The intervention was feasible, improved quality of life and modifiable risk factors: metabolic (BMI, insulin resistance), microbiome (diversity, composition), and immune (inflammation, monocyte subsets). Disease-progression trajectory improved (n=2) or was stable. Findings were translated to Vk*MYC mice modeling the myeloma-precursor state, in which a high-fiber diet delayed disease progression through improved metabolism and microbiome composition leading to increased short-chain fatty acid production that reinvigorated anti-tumor immunity and inhibited tumor growth. These effects from fiber consumption were independent of calorie restriction and weight loss. A high-fiber diet is a low-risk intervention that may delay progression to myeloma.
Authors
- Susan Chimonas (ORCID: https://orcid.org/0000-0002-7742-5950)
- Rúben J. Ramos (ORCID: https://orcid.org/0000-0002-3350-0437)
- Neil M. Iyengar (ORCID: https://orcid.org/0000-0002-9773-5235)
- Heather Jolie Landau (ORCID: https://orcid.org/0000-0002-3152-1189)
- Marcel R.M. van den Brink (ORCID: https://orcid.org/0000-0003-0696-4401)
- P. Leif Bergsagel (ORCID: https://orcid.org/0000-0003-1523-7388)
- Kylee H. Maclachlan (ORCID: https://orcid.org/0000-0001-7873-4854)
- Michaël Pollak (ORCID: https://orcid.org/0000-0003-3047-0604)
- Marta Chesi (ORCID: https://orcid.org/0000-0002-4024-8225)
- Justin R. Cross (ORCID: https://orcid.org/0000-0002-6356-057X)
- Nicola Clementi (ORCID: https://orcid.org/0000-0002-1822-9861)
- Saad Z. Usmani (ORCID: https://orcid.org/0000-0002-5484-8731)
- Oscar Boutros Lahoud (ORCID: https://orcid.org/0000-0002-3291-286X)
- Kinga Hosszu (ORCID: https://orcid.org/0000-0002-1190-1491)
- Jenna Blaslov (ORCID: https://orcid.org/0000-0002-2871-457X)
- Malin L. Hultcrantz (ORCID: https://orcid.org/0000-0002-9045-6495)
- Brianna Gipson (ORCID: https://orcid.org/0009-0005-5837-8676)
- Matteo Bellone (ORCID: https://orcid.org/0000-0002-2586-2569)
- Gunjan L. Shah (ORCID: https://orcid.org/0000-0002-9977-0456)
- Urvi Ashok Shah (ORCID: https://orcid.org/0000-0001-8419-1091)
- Susan DeWolf (ORCID: https://orcid.org/0000-0002-2754-3537)
- Alexander M. Lesokhin (ORCID: https://orcid.org/0000-0001-9321-702X)
- Juan‐José Garcés (ORCID: https://orcid.org/0000-0001-9235-4671)
- Jonathan U. Peled (ORCID: https://orcid.org/0000-0002-4029-7625)
- Anita D’Souza (ORCID: https://orcid.org/0000-0002-1092-5643)
- Sofia Sisti (ORCID: https://orcid.org/0000-0002-8006-7218)
- Nathan Aleynick (ORCID: https://orcid.org/0000-0002-3726-1285)
- Michael Scordo (ORCID: https://orcid.org/0000-0002-9484-0240)
- Torin Block (ORCID: https://orcid.org/0000-0001-5399-1950)
- Leonardo Boiocchi (ORCID: https://orcid.org/0000-0001-5188-6217)
- Erica Salehi (ORCID: https://orcid.org/0000-0003-1081-2216)
- Paola Zordan (ORCID: https://orcid.org/0000-0001-6915-5535)
- Peter A. Adintori (ORCID: https://orcid.org/0000-0001-7099-1143)
- Sara Pagani (ORCID: https://orcid.org/0009-0001-2842-4089)
- Devin McAvoy (ORCID: https://orcid.org/0000-0001-7807-6775)
- David J. Chung (ORCID: https://orcid.org/0000-0003-0469-839X)
- Aishwarya Anuraj (ORCID: https://orcid.org/0009-0007-0139-5568)
- Hani Hassoun (ORCID: https://orcid.org/0000-0002-2036-1749)
- Sandeep S. Raj (ORCID: https://orcid.org/0000-0003-4629-0528)
- Sham Mailankody (ORCID: https://orcid.org/0000-0002-2815-9561)
- Neha Korde (ORCID: https://orcid.org/0000-0002-5538-4318)
- Marco Lorenzoni (ORCID: https://orcid.org/0000-0002-3040-0633)
- Ana Gradíssimo (ORCID: https://orcid.org/0000-0003-1621-6693)
- Richard P. Koche (ORCID: https://orcid.org/0000-0002-6820-5083)
- Francesca Castro (ORCID: https://orcid.org/0000-0003-2023-5483)
- Sergio A. Giralt (ORCID: https://orcid.org/0000-0003-1944-5053)
- Matteo Grioni (ORCID: https://orcid.org/0000-0002-9930-042X)
- Andriy Derkach (ORCID: https://orcid.org/0000-0003-2178-8493)
- Ola Landgren (ORCID: https://orcid.org/0000-0001-6485-4839)
- Ronan Chaligné (ORCID: https://orcid.org/0000-0003-4332-3291)
- J Paredes (ORCID: https://orcid.org/0009-0004-9341-0187)
- Laura Lucia Cogrossi (ORCID: https://orcid.org/0000-0002-7479-4320)
- Charlotte Pohl (ORCID: https://orcid.org/0000-0001-8194-3147)
- Carlyn Rose C. Tan (ORCID: https://orcid.org/0000-0001-7922-2594)
- Anna Policastro (ORCID: https://orcid.org/0009-0009-2388-6098)
- Mirae Baichoo (ORCID: https://orcid.org/0000-0002-4219-9076)
- Teng Fei (ORCID: https://orcid.org/0000-0001-7888-1715)
- Victoria Zinsmeyer (ORCID: https://orcid.org/0009-0002-8549-6158)
- Camilla Marchigiani (ORCID: https://orcid.org/0009-0006-9035-2473)
Institutions
- City Of Hope National Medical Center (US)
- Northwell Health (US)
- Memorial Sloan Kettering Cancer Center (US)
- Vita-Salute San Raffaele University (IT)
- Medical College of Wisconsin (US)
- Cornell University (US)
- San Raffaele University of Rome (IT)
- Kettering University (US)
- NYU Langone Health (US)
- City of Hope (US)
- Mayo Clinic in Arizona (US)
- IRCCS Ospedale San Raffaele (IT)
- NutritionQuest (United States) (US)
- Sylvester Comprehensive Cancer Center (US)
- McGill University (CA)
- New York University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-1101
- Citations
- 5
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.85