Challenges in the management of patients with vascular Ehlers-Danlos syndrome: lessons from three clinical cases

Vascular Ehlers-Danlos syndrome (vEDS) is a rare inherited connective tissue disorder marked by extreme arterial fragility, requiring high clinical suspicion to avoid misdiagnosis and inappropriate interventions.Strict adherence to evidence-based pharmacological therapy and structured long-term follow-up are crucial, as treatment discontinuation may lead to rapid and life-threatening vascular events.Management should be centralized in expert centres with a multidisciplinary approach, where individualized and predominantly conservative strategies can optimize outcomes in this high-risk population.