The proteomics of the giant cedratvirus particles reveals unique and shared features with pitho-like viruses

There are still only a few studies on the proteomics of giant viruses. Research published to date has revealed the presence of several proteins involved in processes such as transcription (including RNA polymerase subunits, helicases, and transcription factors), DNA topology regulation (e.g., topoisomerases), and metabolic pathways (e.g., enzymes that help the virus cope with host oxidative stress). Proteomic studies of giant viruses are important, as understanding the role of these proteins can provide information about viral biology, host-virus interactions, and viral evolution. Here, we present, for the first time to our knowledge, a proteomic analysis of a cedratvirus, highlighting unique and shared features with pithovirus, a relative.