Efficacy and Safety of Tsumura Ninjin'yoeito for Loss of Appetite and Apathy in Patients With Alzheimer's Disease or Dementia With Lewy Bodies: A Multicentre, Open‐Label, Randomised, Comparative Study
Although the primary endpoint did not reach statistical significance, likely due to insufficient sample size, the NYT group showed a significant improvement in food intake, a secondary outcome measure. Furthermore, exploratory post hoc subgroup analysis suggested that NYT may improve appetite in patients with more severe appetite loss at baseline. These findings indicate the potential role of NYT in appetite improvement in patients with AD or DLB, warranting further investigation.
Authors
- Taro Shindo
- Masaru HIGUCHI
- Tetsuaki Arai (ORCID: https://orcid.org/0000-0003-4355-3900)
- Tomio Jinnouchi (ORCID: https://orcid.org/0000-0002-4370-4521)
- Koichi Ikeda (ORCID: https://orcid.org/0009-0002-6562-7472)
- Motoshi Tamura (ORCID: https://orcid.org/0009-0008-0959-1499)
- Makoto Ohsawa
- Kazunori Okahara
- Takashi Asada (ORCID: https://orcid.org/0000-0002-2482-8289)
- Koji Suzuki (ORCID: https://orcid.org/0000-0001-5354-1044)
- Hiroshige Sato
- Katsutoshi Furukawa (ORCID: https://orcid.org/0000-0002-8047-4606)
- Takashi Fukasawa
- Kengo Uemura
Institutions
- Suzuki (Japan) (JP)
- University of Tsukuba (JP)
- Aomori Rosai Hospital (JP)
- Mito Saiseikai General Hospital (JP)
- Ohkawara Neurosurgical Hospital (JP)
- Kagoshima University Hospital (JP)
- JA Toride Medical Center (JP)
- Rainbow Medical (Israel) (IL)
- Ono Clinic (JP)
- University of Miyazaki Hospital (JP)
- Tohoku Medical and Pharmaceutical University Hospital (JP)
- Noguchi Hospital (JP)
- Isesaki Fukushima Hospital (JP)
- Institute of Applied Biochemistry (JP)
- Tohoku Medical and Pharmaceutical University (JP)
Publication Details
- Journal
- Psychogeriatrics
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1111/psyg.70120
- Primary Topic
- Medicinal Plants and Neuroprotection
- Type
- article
- Field-Weighted Citation Impact
- 0.00