Integrative multi-omics identifies endoplasmic reticulum stress-related prognostic biomarkers and CD99-mediated cell–cell communication in lung adenocarcinoma
This study comprehensively analyzes ERS heterogeneity in LUAD, identifying novel key genes involved in the regulation of tumor proliferation, chemotherapy sensitivity, anti-tumor immunity, TME remodeling, and CCC networks. Furthermore, it highlights the critical role of CD99 -mediated CCC in ERS, offering potential biomarkers and therapeutic targets for LUAD.
Authors
- Han Yang (ORCID: https://orcid.org/0000-0001-8320-0830)
- Hong Yang (ORCID: https://orcid.org/0000-0002-6707-8481)
- Liu-Rong Mao
- Weidong Wang
- Peng Lin (ORCID: https://orcid.org/0000-0003-3760-5575)
- Yawei Liu (ORCID: https://orcid.org/0000-0003-4535-5019)
- Yi Rong (ORCID: https://orcid.org/0000-0001-6142-2416)
- Xiayu Fu (ORCID: https://orcid.org/0000-0001-6181-2916)
- Hao‐Xian Yang (ORCID: https://orcid.org/0000-0002-1940-3657)
- Kong jia Luo
- Jun-Ye Wang
Institutions
- Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1097/js9.0000000000003888
- Citations
- 2
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.30