Iron status and cancer risk across 14 cancers: evidence from cross-sectional analyses and a three-stage Mendelian randomization
Genetic evidence suggests that iron status is linked to risks of ovarian (though potentially influenced by smoking), liver, and cervical cancer through metabolic pathways. These findings generate novel hypotheses identifying iron as a modifiable determinant of cancer susceptibility and underscore the need for further investigation into iron modulation as a potential strategy for cancer prevention and therapy.
Authors
- Jiang-Dong Sui (ORCID: https://orcid.org/0000-0001-5171-1978)
- Yuwei Wang (ORCID: https://orcid.org/0000-0001-8819-3844)
- Yu He (ORCID: https://orcid.org/0000-0003-4898-5518)
- Zhili Wang (ORCID: https://orcid.org/0000-0003-0403-5705)
- Wei Zhou (ORCID: https://orcid.org/0000-0001-7534-3065)
- Bin Long
- Xiaolei Shu
Institutions
- Chongqing University (CN)
- Chongqing Cancer Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1097/js9.0000000000004245
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00