Engineering tunable GTP/TPi-responsive liposomes through liposomal membrane modulation using a bis-triphenylphosphonium lipid switch
Liposomes incorporating a bis-phosphonium lipid switch exhibit tunable cargo release triggered by GTP or TPi. Modulating lipid ratios within the liposome controls metabolite selectivity and release kinetics for responsive cargo delivery.
Authors
- Charlotte Russell (ORCID: https://orcid.org/0000-0002-8194-8033)
- Michael D. Best (ORCID: https://orcid.org/0000-0001-8737-5910)
- Brian J. Smith (ORCID: https://orcid.org/0000-0003-0498-1910)
- Maria Mustafa (ORCID: https://orcid.org/0000-0001-5554-4978)
Institutions
- University of Tennessee at Knoxville (US)
Publication Details
- Journal
- RSC Pharmaceutics
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1039/d5pm00206k
- Primary Topic
- Lipid Membrane Structure and Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Division of Materials Research