Early rhythm control in patients with acute decompensated heart failure: results from the CYCLE cohort study
Rapid CommunicationAtrial fibrillation (AF) is common in patients with acute decompensated heart failure (HF).Both conditions share risk factors, e.g.hypertension, diabetes, coronary artery disease, and aggravate each other. 1 AF increases the risk of stroke, HF hospitalization, and mortality in acute decompensated HF. 2 Rhythm control in this population remains challenging due to frequent recurrences and limited therapeutic options.Early rhythm control reduces a composite outcome of cardiovascular death, stroke, or HF hospitalization by 21% compared with usual care in patients with AF and comorbidities, with consistent results in patients with AF and HF. 3,4 hile recent analyses indicate potential early benefits of rhythm control, the last randomized trial testing rhythm control in acute decompensated HF, ANDROMEDA, was halted nearly 20
Authors
- Gianluigi Savarese (ORCID: https://orcid.org/0000-0001-7732-0887)
- Christina Magnussen (ORCID: https://orcid.org/0000-0002-5102-0955)
- Stefan Blankenberg (ORCID: https://orcid.org/0000-0001-6488-2362)
- Lisa Besch
- Caroline Kellner (ORCID: https://orcid.org/0009-0000-9693-4622)
- Benedikt Schrage (ORCID: https://orcid.org/0000-0001-9041-3922)
- Paulus Kirchhof (ORCID: https://orcid.org/0000-0002-1881-0197)
- Nina Becher (ORCID: https://orcid.org/0000-0002-4476-1341)
- Benedikt N. Beer (ORCID: https://orcid.org/0000-0003-4315-2533)
- Jonas Sundermeyer (ORCID: https://orcid.org/0000-0002-0076-2211)
- Marvin Kriz (ORCID: https://orcid.org/0009-0003-0823-2834)
- Angela Dettling (ORCID: https://orcid.org/0000-0003-0992-0236)
- Maria Luisa Benesch Vidal (ORCID: https://orcid.org/0009-0002-2303-7976)
- Peter Moritz Becher (ORCID: https://orcid.org/0000-0003-1221-7015)
Institutions
- Tufts Medical Center (US)
- Universität Hamburg (DE)
- Danderyds sjukhus (SE)
- Karolinska Institutet (SE)
- Stockholm South General Hospital (SE)
- University Medical Center Hamburg-Eppendorf (DE)
- German Centre for Cardiovascular Research (DE)
- University of Birmingham (GB)
Publication Details
- Journal
- EP Europace
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1093/europace/euaf314
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00