Sex differences in the progression of cardiovascular–kidney–metabolic syndrome
In this large nationwide cohort, CKM stage progression was associated with higher CVD risk in both sexes, with modest sex-specific differences. These findings highlight the value of CKM staging for early risk assessment, regardless of sex.
Authors
- Norihiko Takeda (ORCID: https://orcid.org/0000-0003-1023-6116)
- Yuta Suzuki (ORCID: https://orcid.org/0000-0002-9406-4691)
- Hidehiro Kaneko (ORCID: https://orcid.org/0000-0003-2553-6170)
- Hiroyuki Morita
- Norifumi Takeda (ORCID: https://orcid.org/0000-0003-4818-3347)
- Shinsuke Yuasa (ORCID: https://orcid.org/0000-0001-5593-7552)
- Akira Okada (ORCID: https://orcid.org/0000-0001-6480-3388)
- Katsuhito Fujiu
- Masaomi Nangaku (ORCID: https://orcid.org/0000-0001-7401-2934)
- Kaori Hayashi (ORCID: https://orcid.org/0000-0002-4923-1550)
- Takahiro Jimba (ORCID: https://orcid.org/0000-0002-3757-3959)
- Koichi Node (ORCID: https://orcid.org/0000-0002-2534-0939)
- Kentaro Ejiri (ORCID: https://orcid.org/0000-0001-6645-2075)
- Satoshi Taya
- Toru Miyoshi (ORCID: https://orcid.org/0000-0002-9039-3439)
- Hideo Yasunaga (ORCID: https://orcid.org/0000-0002-6017-469X)
- Toshiyuki Ko (ORCID: https://orcid.org/0000-0002-9043-064X)
- Atsushi Mizuno
- Tatsuhiko Azegami
Institutions
- Okayama University (JP)
- Saga University (JP)
- Keio University (JP)
- St. Luke's International Hospital (JP)
- National Institute of Public Health (JP)
- University of Tokyo Hospital (JP)
- University of Tokyo Health Sciences (JP)
- Integrative Medicine Institute (US)
- Department of Health (IE)
- The University of Tokyo (JP)
Publication Details
- Journal
- European Heart Journal Open
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1093/ehjopen/oeaf162
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Boston Scientific Corporation
- Boston Scientific Japan
- Ministry of Health, Labour and Welfare
- Medtronic Japan