Collaborative framework on responsible AI in LLM-driven CDSS for precision oncology leveraging real-world patient data
Precision oncology leverages real-world data, essential for identifying biomarkers and therapies. Large language models (LLMs) can aid at structuring unstructured data, overcoming current bottlenecks in precision oncology. We propose a framework for responsible LLM integration into precision oncology, co-developed by multidisciplinary experts and supported by Cancer Core Europe. Five thematic dimensions and ten principles for practice are outlined and illustrated through application to uterine carcinosarcoma in a thought experiment.
Authors
- Raquel Pérez-López (ORCID: https://orcid.org/0000-0002-9176-0130)
- Maximilian Tschochohei
- Kai Joachim Borm (ORCID: https://orcid.org/0009-0005-8580-890X)
- Luise Modersohn (ORCID: https://orcid.org/0000-0002-8258-4366)
- Jacqueline Lammert (ORCID: https://orcid.org/0000-0002-0380-574X)
- Martin Boeker (ORCID: https://orcid.org/0000-0003-2972-2042)
- Dyke Ferber (ORCID: https://orcid.org/0009-0006-6195-9276)
- Simon Kreutzfeldt (ORCID: https://orcid.org/0000-0003-3278-4586)
- Fredrik Strand (ORCID: https://orcid.org/0000-0003-3910-7086)
- Sonja Mathes (ORCID: https://orcid.org/0000-0001-5770-762X)
- Jakob Nikolas Kather (ORCID: https://orcid.org/0000-0002-3730-5348)
- Theresa Willem (ORCID: https://orcid.org/0000-0001-7643-8816)
- Richard J. Dirven (ORCID: https://orcid.org/0000-0001-9626-9925)
- Richard D. Baird (ORCID: https://orcid.org/0000-0001-7071-6483)
- Tobias F. Dreyer (ORCID: https://orcid.org/0000-0002-5366-7859)
- Arsela Prelaj
- Julien Vibert
Institutions
- Karolinska University Hospital (SE)
- Radboud University Nijmegen (NL)
- German Cancer Research Center (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- Institut Gustave Roussy (FR)
- University Hospital Heidelberg (DE)
- Radboud University Medical Center (NL)
- Karolinska Institutet (SE)
- The Netherlands Cancer Institute (NL)
- Helmholtz Zentrum München (DE)
- Cancer Research UK Cambridge Center (GB)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Fresenius (Germany) (DE)
- National Center for Tumor Diseases (DE)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Vall d'Hebron Institute of Oncology (ES)
- Technical University of Munich (DE)
Publication Details
- Journal
- npj Precision Oncology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1038/s41698-025-01180-5
- Primary Topic
- Artificial Intelligence in Healthcare and Education
- Type
- article
- Field-Weighted Citation Impact
- 0.00