The interplay of circadian syndrome and biological aging in all-cause mortality: a stratified mediation analysis by cancer status
CircS is associated with accelerated biological aging. Biological aging is a critical pathway linking CircS to mortality, especially among cancer survivors. These findings highlight the importance of circadian health in the aging process and suggest that biological age may be a potential therapeutic target for mitigating mortality risk, particularly in cancer survivors.
Authors
- Han Yu (ORCID: https://orcid.org/0000-0001-6160-173X)
- Xue Chen (ORCID: https://orcid.org/0000-0003-3663-3582)
- Longshan Yang (ORCID: https://orcid.org/0000-0002-7885-6189)
- Zeyi Zhang (ORCID: https://orcid.org/0000-0001-5567-5951)
- Heng Cao (ORCID: https://orcid.org/0000-0001-6160-3997)
Institutions
- Shandong Provincial Hospital (CN)
- Zhujiang Hospital (CN)
- Shandong First Medical University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1097/js9.0000000000004301
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00