Suppression of <scp>RBC</scp> alloimmunization and regulation of <scp> CD4 <sup>+</sup> T </scp> cell dependence by <scp>C3</scp> is not due to genetic confounders in mice
The current findings eliminate a common confounder present in murine knockout systems that has caused erroneous conclusions in other settings. Both the conclusion that the presence of the C3 gene decreases RBC alloimmunization and regulates CD4<sup>+</sup> T cell dependence was confirmed.
Authors
- Arijita Jash (ORCID: https://orcid.org/0000-0001-9613-4932)
- Ariel Hay (ORCID: https://orcid.org/0000-0002-9003-6415)
- James C. Zimring (ORCID: https://orcid.org/0000-0002-6365-8825)
Institutions
- Carter Center (US)
- University of Virginia (US)
Publication Details
- Journal
- Transfusion
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1111/trf.70026
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute