AlphaGenome, a Swiss-army knife for exploring non-coding DNA
AlphaGenome, recently announced in a preprint by Avsec et al., is Google DeepMind's powerful 'Swiss army knife' for predicting molecular effects from non-coding DNA. Remarkably, it does so with base-pair resolution while maintaining long-range context. Here, we discuss AlphaGenome's promise and limitations in prioritizing and functionally interpreting non-coding variants underlying human traits and diseases.
Authors
- Judit García‐González (ORCID: https://orcid.org/0000-0001-6245-740X)
- Krzysztof Gogolewski (ORCID: https://orcid.org/0000-0001-5523-5198)
Institutions
- Mount Sinai Hospital (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Trends in Genetics
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.tig.2025.11.007
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82