Brain atrophy and cholinergic denervation in progressive supranuclear palsy: an MRI and [18F]-FEOBV PET study
Structural brain changes associated with higher MRPI 2.0 index scores may be a reliable proxy measure of cholinergic terminal deficits in PSP, predominantly those in subcortical regions. Differential association of subcortical brain region cholinergic deficits with PSP-specific structural brain changes may reflect the characteristic pattern of 4R-tau pathology observed in PSP.
Authors
- Roger L. Albin (ORCID: https://orcid.org/0000-0002-0629-608X)
- Jaimie Barr
- Prabesh Kanel (ORCID: https://orcid.org/0000-0003-1418-2960)
- C. Chauncey Spears (ORCID: https://orcid.org/0000-0002-7562-1608)
- Peter J. H. Scott (ORCID: https://orcid.org/0000-0002-6505-0450)
- Stiven Roytman (ORCID: https://orcid.org/0000-0001-8823-3287)
- Robert Vangel (ORCID: https://orcid.org/0009-0001-1049-1937)
- Fotini Michalakis (ORCID: https://orcid.org/0009-0006-0836-445X)
- Nicolaas Ida Bohnen (ORCID: https://orcid.org/0000-0003-0352-6414)
- Giulia Carli
Institutions
- University of Michigan (US)
- VA Ann Arbor Healthcare System (US)
- Geriatric Research Education and Clinical Center (US)
- Parkinson's Foundation (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fnins.2025.1695541
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Parkinson's Foundation
- National Institutes of Health