Prostate Cancer Risk and DNA Mismatch Repair Deficiency Among Lynch Syndrome Patients
In this study, we looked at the incidence and characteristics of prostate cancer that develops among individuals with Lynch syndrome. We found that individuals with Lynch syndrome have an elevated risk of developing prostate cancer, but this risk varied by Lynch syndrome gene and family history. This information will help guide targeted prostate cancer screening and management for individuals with Lynch syndrome.
Authors
- Andrew Gusev (ORCID: https://orcid.org/0000-0003-1480-8716)
- Keyan Salari (ORCID: https://orcid.org/0000-0001-7940-4558)
- Mariana Santos Cruz (ORCID: https://orcid.org/0000-0001-5959-7153)
- Nick Kamkari (ORCID: https://orcid.org/0000-0002-6922-0306)
- Chin‐Lee Wu (ORCID: https://orcid.org/0000-0002-0444-0068)
- Linda Rodgers (ORCID: https://orcid.org/0000-0002-3956-5821)
- Daniel C. Chung (ORCID: https://orcid.org/0000-0001-8226-7005)
- Sara I. Justiniano
Institutions
- Broad Institute (US)
- Massachusetts General Hospital (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.euros.2025.11.006
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00