Neoadjuvant Chemotherapy Prior to Trimodality Therapy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis
We reviewed studies in which chemotherapy was given before a bladder-sparing approach, called trimodality therapy (tumor removal plus chemoradiation). Overall, this treatment approach did not improve survival, although patients who responded to the pretreatment did better. Newer drugs, including immunotherapy, should be tested in this setting.
Authors
- Keiichiro Miyajima (ORCID: https://orcid.org/0000-0002-7799-669X)
- Akihiro Matsukawa (ORCID: https://orcid.org/0000-0002-3324-762X)
- Navid Roessler (ORCID: https://orcid.org/0009-0008-2792-9828)
- Fumihiko Urabe (ORCID: https://orcid.org/0000-0002-2599-8183)
- Ahmed R Alfarhan
- Keiichiro Mori (ORCID: https://orcid.org/0000-0002-6147-6569)
- Takafumi Yanagisawa (ORCID: https://orcid.org/0000-0002-7410-0712)
- Marcin Miszczyk (ORCID: https://orcid.org/0000-0002-4375-0827)
- Shota Inoue
- Abdulrahman Alqahtani (ORCID: https://orcid.org/0000-0002-6658-3240)
- Takahiro Kimura (ORCID: https://orcid.org/0000-0002-5673-1553)
- Pierre I. Karakiewicz (ORCID: https://orcid.org/0000-0003-1354-5854)
- Shahrokh F. Shariat
Institutions
- Semmelweis University (HU)
- Al-Ahliyya Amman University (JO)
- Jikei University School of Medicine (JP)
- Universität Hamburg (DE)
- Okayama University (JP)
- Cornell University (US)
- Comprehensive Cancer Center Vienna (AT)
- University Medical Center Hamburg-Eppendorf (DE)
- Ministry of Health (SA)
- Ministry of Health (MM)
- WSB University (PL)
- Karl Landsteiner Society (AT)
- Université de Montréal (CA)
- Medical University of Vienna (AT)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.euros.2025.11.005
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00