Fusion of Tumor Cells with Lipid-Associated Macrophages Drives Metastatic Progression of Breast Cancer
Single-cell transcriptomic profiling combined with functional and clinical validation identifies fusion of tumor cells and lipid-associated macrophages mediated by the CBX3-SNX10-ANO6 axis as a potentially targetable mechanism driving cancer metastasis.
Authors
- Guanqiao Li (ORCID: https://orcid.org/0000-0002-1999-2519)
- Yi Lü (ORCID: https://orcid.org/0000-0002-1060-6925)
- Xin Hong (ORCID: https://orcid.org/0000-0002-9671-0116)
- Lianhui Duan (ORCID: https://orcid.org/0009-0005-8160-2226)
- Boxi Zhao (ORCID: https://orcid.org/0000-0001-6014-977X)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-3702-2946)
- Jingru Lian (ORCID: https://orcid.org/0000-0001-9693-5078)
- Siqi Chen (ORCID: https://orcid.org/0009-0003-7260-3070)
- Jing Cao (ORCID: https://orcid.org/0000-0001-9302-4850)
- Yixin Cheng (ORCID: https://orcid.org/0000-0003-4545-5829)
- Liping Wu (ORCID: https://orcid.org/0009-0002-3880-1025)
- Zhen-Yu He (ORCID: https://orcid.org/0000-0003-1402-8963)
- Shun Zheng (ORCID: https://orcid.org/0009-0004-3643-895X)
- Hao Yu (ORCID: https://orcid.org/0000-0003-2793-7912)
- Feiqiu Wen (ORCID: https://orcid.org/0000-0002-3551-738X)
- Xuefei Liu (ORCID: https://orcid.org/0000-0002-1843-6107)
- Jun Tan (ORCID: https://orcid.org/0000-0001-6275-1326)
- Yang Yang (ORCID: https://orcid.org/0009-0001-8327-4124)
- Wenjing Wang (ORCID: https://orcid.org/0009-0006-7638-0478)
- Chun Wu (ORCID: https://orcid.org/0000-0001-5003-1460)
- Guanyin Huang (ORCID: https://orcid.org/0009-0004-6049-111X)
- Yufan Yang (ORCID: https://orcid.org/0009-0004-3402-8770)
- Tianyu Zha (ORCID: https://orcid.org/0009-0001-0596-6184)
Institutions
- Central South University (CN)
- Sun Yat-sen University (CN)
- Southern University of Science and Technology (CN)
- Hunan Cancer Hospital (CN)
- Hainan General Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Sun Yat-sen University Cancer Center (CN)
- Shenzhen Technology University (CN)
- Shenzhen Children's Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0261
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80