Asymmetric synthesis of isoindolines <i>via</i> a palladium-catalyzed enantioselective intramolecular oxidative aminoacetoxylation reaction

Here, we report a palladium-catalyzed asymmetric intramolecular oxidative aminoacetoxylation reaction employing triazole-oxazoline ligands, which enables the direct construction of a chiral isoindoline scaffold. A series of chiral isoindolines bearing vicinal stereocenters were obtained in moderate to high yields and good enantiomeric ratios under mild conditions.