Bruceine A Alleviates Lung Injury In Sepsis-Associated Acute Respiratory Distress Syndrome By Modulating Macrophage Polarization And NF-?B Pathway Activity

BA protects against LPS-induced ARDS in mice by modulating cytokine release, promoting M2 macrophage polarization and suppressing NF-κB activation. These findings suggest BA as a promising natural immunomodulatory agent for inflammatory lung diseases.