Osimertinib induces reversible cardiac dysfunction through the GATA4-MYLK3-MYL2 axis
These findings suggest that osimertinib causes reversible cardiac dysfunction by disrupting MYL2 phosphorylation via GATA4 dephosphorylation-mediated suppression of MYLK3 and highlight the potential of myosin activation as a preventive or rescue strategy for osimertinib cardiotoxicity.
Authors
- Alyssa Ayala
- Xiwei Wu (ORCID: https://orcid.org/0000-0002-7071-1671)
- Dan J. Raz (ORCID: https://orcid.org/0000-0001-7054-6656)
- Christian H. Nenninger (ORCID: https://orcid.org/0009-0008-7580-5328)
- Ignacio Norambuena‐Soto (ORCID: https://orcid.org/0000-0002-2676-2674)
- James Aboagye
- Katie Huang (ORCID: https://orcid.org/0000-0001-5589-7212)
- Zhao V. Wang (ORCID: https://orcid.org/0000-0002-9904-9538)
- Jenaro Espitia-Corredor (ORCID: https://orcid.org/0000-0003-2454-9746)
- Yin Wang (ORCID: https://orcid.org/0000-0002-2508-7881)
- Shu Tao (ORCID: https://orcid.org/0000-0001-5177-6771)
- Yingfeng Deng (ORCID: https://orcid.org/0000-0003-1314-5105)
- June‐Wha Rhee (ORCID: https://orcid.org/0000-0002-7044-2985)
- Huaxiao Yang (ORCID: https://orcid.org/0000-0001-9335-8201)
- J. Jefferson P. Perry (ORCID: https://orcid.org/0000-0001-9889-3502)
- Vertica Agnihotri (ORCID: https://orcid.org/0000-0003-2068-8773)
- Paul P. Cheng (ORCID: https://orcid.org/0000-0003-3429-2702)
- Kai Zhang (ORCID: https://orcid.org/0009-0009-7164-9556)
- Zhen Chen
- Guosheng Fu (ORCID: https://orcid.org/0000-0001-7027-0717)
- Brittany Echevarria (ORCID: https://orcid.org/0009-0000-4099-3041)
Institutions
- University of North Texas (US)
- City Of Hope National Medical Center (US)
- Sir Run Run Shaw Hospital (CN)
- City of Hope (US)
- University of California, Davis (US)
- Stanford University (US)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1093/eurheartj/ehaf813
- Citations
- 3
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.31