Deciphering N7-methylguanosine-driven immune dysregulation in unexplained recurrent spontaneous abortion based on transcriptome data and experimental validation
This study establishes m7G methylation as a novel epigenetic driver of immune dysregulation in URSA. The predictive signature offers translational tool for risk stratification and targeted therapy, bridging RNA epigenetics with reproductive immunology.
Authors
- Sujie Song
- Xiaoxuan Zhao
- Shimeng Wang (ORCID: https://orcid.org/0000-0002-7745-1630)
- Qing Guo
Institutions
- Zhejiang Chinese Medical University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Heilongjiang Academy of Sciences (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1186/s40001-025-03585-1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00