The Inflammatory Skin Disease map: an interactive computational resource focused on molecular mechanisms in psoriasis and atopic dermatitis
In this research letter, we introduce the Inflammatory Skin Diseases (ISD) map, a visual and computational representation of a molecular interaction network of molecular mechanisms of atopic dermatitis (AD) and psoriasis (PsO) (https://disease-maps.io/isd/). This knowledge repository can be used as a graphical review, to visualize complex omics data, or as a simulation testbed for research hypotheses. The purpose of the ISD map is to represent key molecular mechanisms of AD and PsO, facilitating information search and data interpretation, and supporting computational analyses.
Authors
- Nick Dand (ORCID: https://orcid.org/0000-0002-1805-6278)
- Matladi Ndlovu
- Marek Ostaszewski (ORCID: https://orcid.org/0000-0003-1473-370X)
- Ravi Ramessur (ORCID: https://orcid.org/0000-0003-4599-9455)
- Joseph Rastrick
- Ahmed Abdelmonem Hemedan (ORCID: https://orcid.org/0000-0001-7403-181X)
- Márcio Luís Acencio (ORCID: https://orcid.org/0000-0002-8278-240X)
- Lavinia Paternoster (ORCID: https://orcid.org/0000-0003-2514-0889)
- Matthias Hübenthal (ORCID: https://orcid.org/0000-0002-5956-3006)
- Reinhard Schneider (ORCID: https://orcid.org/0000-0002-8278-1618)
- Sara Jo Brown (ORCID: https://orcid.org/0000-0002-3232-5251)
- Stephan Weidinger (ORCID: https://orcid.org/0000-0003-3944-252X)
- Venkata Satagopam (ORCID: https://orcid.org/0000-0002-6532-5880)
- Catherine Smith (ORCID: https://orcid.org/0000-0001-9918-1144)
- Soumyabrata Ghosh (ORCID: https://orcid.org/0000-0003-0659-6733)
- Xinhui Wang (ORCID: https://orcid.org/0000-0001-8697-4209)
- Oxana Lopata (ORCID: https://orcid.org/0000-0003-2852-0115)
Institutions
- King's College London (GB)
- University of Luxembourg (LU)
- Edinburgh Cancer Research (GB)
- University of Bristol (GB)
- University Hospital Schleswig-Holstein (DE)
- Institute of Dermatology (TH)
- UCB Pharma (United Kingdom) (GB)
- MRC Epidemiology Unit (GB)
- Arbed (Luxembourg) (LU)
- University of Lübeck (DE)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1093/bjd/ljaf491
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université du Luxembourg
- European Federation of Pharmaceutical Industries and Associations
- King's College London
- European Commission
- University of Bristol
- Medical Research Council
- UCB Pharma
- Institute of Genetics