Mesenchymal stem cell–derived exosome delivery of let-7a-5p enhances macrophage efferocytosis via Arid3a/Mertk axis in acute-on-chronic liver failure
MSC-Exos enhance macrophage efferocytosis in ACLF via the let-7a-5p/Arid3a/Mertk axis. Engineered MSC-Exoslet-7a-5p, by boosting this pathway, provide a potential strategy for improving ACLF therapy.
Authors
- Bingliang Lin (ORCID: https://orcid.org/0000-0003-4069-6287)
- Wei Liang (ORCID: https://orcid.org/0000-0002-4725-9605)
- Junyi Wang (ORCID: https://orcid.org/0000-0002-4329-2854)
- Zhouhan Wang (ORCID: https://orcid.org/0000-0002-2500-7247)
- Jun-feng Chen (ORCID: https://orcid.org/0000-0001-9234-9098)
- Jing Zhang (ORCID: https://orcid.org/0000-0003-4314-3960)
- Zhihui Li (ORCID: https://orcid.org/0000-0002-4998-1909)
- Jialei Wang (ORCID: https://orcid.org/0000-0001-6944-9613)
- Shibo Meng
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Stem Cells Translational Medicine
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1093/stcltm/szaf058
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00