Elevated neurofilament light levels in acute anorexia nervosa are associated with alterations in white matter volume and connectivity networks
The results suggest that WM volume reductions in acute AN might be related to axonal damage. The NBS results indicate, that the elevated fractional anisotropy previously found in AN might be related to damage processes leading to axonal swelling. All in all, the present study supports NF-L as a global blood marker for brain damage processes in acute AN.
Authors
- Stefan Ehrlich (ORCID: https://orcid.org/0000-0003-2132-4445)
- Katja Akgün (ORCID: https://orcid.org/0000-0003-1371-5032)
- Inger Hellerhoff (ORCID: https://orcid.org/0000-0002-6152-5834)
- Fabio Bernardoni (ORCID: https://orcid.org/0000-0002-5112-405X)
- Daniel Geisler (ORCID: https://orcid.org/0000-0003-2076-5329)
- David M. Poitz (ORCID: https://orcid.org/0000-0001-7803-1972)
- Friederike I. Tam (ORCID: https://orcid.org/0000-0001-8333-867X)
- Veit Roessner (ORCID: https://orcid.org/0000-0002-1873-7081)
- Arne Doose (ORCID: https://orcid.org/0000-0002-5026-1239)
- Tjalf Ziemssen (ORCID: https://orcid.org/0000-0001-8799-8202)
- Nina Chotjewitz
Institutions
- Klinikum Arnsberg (DE)
- University Hospital Carl Gustav Carus (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Journal of Child Psychology and Psychiatry
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1111/jcpp.70083
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Celgene
- B. Braun-Stiftung
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Technische Universität Dresden
- Shire
- Servier
- Schweizerische Anorexia Nervosa Stiftung
- Christina Barz-Stiftung
- National Institute of Mental Health