Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Antitumor Immunity
Targeting SCUBE3 with a neutralizing antibody inhibits tumor growth and metastasis by blocking oncogenic signaling through FOXR2 and c-Myc and by circumventing immunosuppression, providing a promising pan-cancer treatment approach.
Authors
- Maria E. Falzone (ORCID: https://orcid.org/0000-0001-6738-7017)
- Robert Hromas (ORCID: https://orcid.org/0000-0002-1916-6276)
- Shahad Abdulsahib (ORCID: https://orcid.org/0000-0002-0073-1570)
- Rahul Mojidra
- Suryavathi Viswanadhapalli
- Deepika Singh (ORCID: https://orcid.org/0000-0002-2407-451X)
- Benjamin Onyeagucha (ORCID: https://orcid.org/0000-0002-2108-0439)
- Jean X. Jiang (ORCID: https://orcid.org/0000-0002-2185-5716)
- Manjeet K. Rao (ORCID: https://orcid.org/0000-0001-7573-2677)
- Alexander B. Taylor (ORCID: https://orcid.org/0000-0003-3517-6033)
- Saif Nirzhor (ORCID: https://orcid.org/0000-0003-4626-7862)
- Jian Yu Huang (ORCID: https://orcid.org/0000-0003-3012-4592)
- Panneerdoss Subbarayalu (ORCID: https://orcid.org/0000-0002-9028-7193)
- Mukund Bhandari (ORCID: https://orcid.org/0000-0001-9648-4844)
- Chris T.P. (ORCID: https://orcid.org/0000-0001-6694-853X)
- Subapriya Rajamanickam (ORCID: https://orcid.org/0009-0003-8342-8319)
- Ratna K. Vadlamudi (ORCID: https://orcid.org/0000-0003-2849-4076)
- Daisy Medina (ORCID: https://orcid.org/0000-0002-2955-5830)
- Patrick Sung (ORCID: https://orcid.org/0000-0003-1396-9040)
- Jack Y. Prochnau (ORCID: https://orcid.org/0000-0003-3243-6346)
- Yidong Chen (ORCID: https://orcid.org/0000-0001-6806-2185)
- Daohong Zhou (ORCID: https://orcid.org/0000-0002-2400-6461)
- Dongwen Lv (ORCID: https://orcid.org/0009-0005-5073-0313)
- Prabhakar Pitta Venkata (ORCID: https://orcid.org/0000-0002-4639-328X)
- Santosh Timilsina (ORCID: https://orcid.org/0000-0002-1315-7539)
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- Mississippi University for Women (US)
- Children's Cancer Center (US)
- The University of Texas at San Antonio (US)
- The University of Texas Southwestern Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0521
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00