Extracts from Plectranthus asirensis and Premna resinosa inhibit Helicobacter pylori-induced epithelial cell damage, DNA double-strand breaks and inflammation
Taken together, we have discovered natural compounds of P. asirensis and P. resinosa that exhibit potent anti-H. pylori activities, not only inhibiting bacterial growth, but also suppressing key virulence mechanisms involved in epithelial cell damage, inflammation and genomic instability. These extracts are promising candidates for future therapeutic applications in patients, which could help minimizing H. pylori infections and gastric cancer development.
Authors
- Nicole Tegtmeyer (ORCID: https://orcid.org/0000-0002-6300-1831)
- Omar M. Noman (ORCID: https://orcid.org/0000-0003-0902-6381)
- Steffen Backert (ORCID: https://orcid.org/0000-0002-8948-8254)
- Mathias Müsken (ORCID: https://orcid.org/0000-0002-5624-1378)
- Bodo Linz (ORCID: https://orcid.org/0000-0003-4987-0587)
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Helmholtz Centre for Infection Research (DE)
Publication Details
- Journal
- Gut Pathogens
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1186/s13099-025-00778-1
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutscher Akademischer Austauschdienst
- Deutsche Forschungsgemeinschaft