Single-cell RNA Sequencing Analysis Reveals the Molecular Mechanisms of Neutrophil Dysfunction in Chronic Bone Infection
Chronic bone infection drives neutrophil polarization toward an N2 anti-inflammatory phenotype, reducing antimicrobial capacity and promoting infection persistence. Targeting neutrophil function may offer new therapeutic strategies for chronic bone infection.
Authors
- Tiejian Li (ORCID: https://orcid.org/0000-0003-0948-5262)
- Yue Song (ORCID: https://orcid.org/0000-0002-7800-5528)
- Hongbin Xie (ORCID: https://orcid.org/0009-0008-2057-9060)
- Wei Chai (ORCID: https://orcid.org/0000-0001-8781-9745)
- S Nan
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-12-04
- DOI
- https://doi.org/10.2174/0109298673432965251027081909
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00