Effectiveness of the antihistamine and anti-PAF effects of rupatadine in allergic diseases: off-label use in a case series study

Rupatadine is a modern, long-acting, non-sedating antihistamine that targets the H₁ receptor and exhibits additional strong antagonist activity toward platelet-activating factor (PAF) receptors as well as exerting other anti-inflammatory effects. All these properties have positioned rupatadine as a remarkable treatment option for adults and children with various allergic and skin disorders, including allergic rhinitis and urticaria of different causes. This case series shows the real-world effectiveness and safety of off-label rupatadine use in paediatric patients with clinically relevant complex allergy-related and dermatology-related conditions, whose underlying pathogenetic mechanisms were successfully addressed by the pharmacological profile of rupatadine.