Partial Post-exposure Protection by Topical Inserts Containing Tenofovir Alafenamide Fumarate/Elvitegravir in a Macaque Model of Rectal Simian HIV (SHIV) Infection
On-demand topical inserts for HIV prevention may be a good option for people who have a low frequency of sexual activity. We recently demonstrated in a preclinical macaque model that rectal application of inserts containing tenofovir alafenamide fumarate (TAF) and elvitegravir (EVG) conferred protection against SHIV infection (93% efficacy) when applied as pre-exposure prophylaxis (PrEP) 4 hours before SHIV exposure. Here, we show that the same inserts provide significant post-exposure protection (82.9% efficacy) when applied four hours after SHIV exposure. Our findings further support the ongoing clinical development of TAF/EVG inserts for on-demand HIV prevention.
Authors
- Jose Gerardo Garcia-Lerma (ORCID: https://orcid.org/0000-0001-6437-7745)
- Kristen Kelley (ORCID: https://orcid.org/0000-0002-4307-3301)
- Walid Heneine (ORCID: https://orcid.org/0000-0003-3119-3565)
- Meredith R. Clark (ORCID: https://orcid.org/0000-0002-4476-8287)
- M. Melissa Peet
- Tyana Singletary
- Maria Mendoza (ORCID: https://orcid.org/0000-0003-1755-394X)
- Yi Pan (ORCID: https://orcid.org/0000-0003-1978-475X)
- Vivek Agrahari (ORCID: https://orcid.org/0000-0002-3837-1777)
- James M. Smith (ORCID: https://orcid.org/0000-0002-7465-6067)
- Natalia Makarova (ORCID: https://orcid.org/0000-0002-7245-009X)
- Ryan Johnson
- Gustavo F. Doncel (ORCID: https://orcid.org/0009-0009-9641-1325)
Institutions
- Centers for Disease Control and Prevention (US)
- Eastern Virginia Medical School (US)
- National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention (US)
- Old Dominion University (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1093/infdis/jiaf611
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00