Evidence for Causal Links Between Known Modifiable Risk Factors and Dementia: A Systematic Review of Mendelian Randomisation Studies
MR evidence for most Lancet Commission risk factors remains insufficient or inconclusive. The most consistent support for causal associations was observed for lower educational attainment and type 2 diabetes. Null findings should be interpreted cautiously given limitations in GWAS phenotyping, sample composition, and MR methodology.
Authors
- Natalie L. Marchant (ORCID: https://orcid.org/0000-0003-0669-6910)
- Verena Zuber (ORCID: https://orcid.org/0000-0001-9827-1877)
- Roopal Desai (ORCID: https://orcid.org/0000-0003-4221-1546)
- Amber John (ORCID: https://orcid.org/0000-0002-8207-7698)
- Georgina Charlesworth (ORCID: https://orcid.org/0000-0002-5278-1756)
- Jean Stafford (ORCID: https://orcid.org/0000-0002-0144-9200)
- Joshua Stott (ORCID: https://orcid.org/0000-0003-1361-053X)
- Emma L. Anderson (ORCID: https://orcid.org/0000-0002-1508-0598)
- Aysha Mohamed Rafik Patel (ORCID: https://orcid.org/0009-0004-4987-8217)
Institutions
- Department of Health and Social Care (GB)
- NIHR Imperial Biomedical Research Centre (GB)
- MRC Unit for Lifelong Health and Ageing (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1111/ene.70458
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00