PINK1 suppresses colorectal cancer cell growth through epigenetic regulation of histone modifications
PINK1 acts as a tumor suppressor in colorectal cancer by inhibiting proliferation and migration, promoting apoptosis, and remodeling the epigenetic landscape through altering histone modifications and enhancing chromatin accessibility.
Authors
- Shijia Luan
- Yunxia Zhu (ORCID: https://orcid.org/0000-0002-4597-4445)
- Meng Wang (ORCID: https://orcid.org/0000-0002-4970-8590)
- Xiang Fan (ORCID: https://orcid.org/0009-0002-7221-3710)
- Dong Han (ORCID: https://orcid.org/0000-0003-4009-8172)
Institutions
- Harbin Medical University (CN)
- Zhejiang Cancer Hospital (CN)
- Hangzhou Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Zhejiang University (Medical Sciences)
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3724/zdxbyxb-2024-0652
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province