CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer
The effects of CPT1a in the heart extend beyond fatty acid oxidation including noncanonical regulation of gene programs. CPT1a upregulation occurs in nonischemic cardiomyopathy and is a critical cardioprotective adaptation to pathological stress.
Authors
- Kenneth B. Margulies (ORCID: https://orcid.org/0000-0002-8093-4465)
- Chandan K. Maurya (ORCID: https://orcid.org/0000-0003-2581-7415)
- Yang Wang (ORCID: https://orcid.org/0009-0005-9052-2279)
- S. Maurya (ORCID: https://orcid.org/0000-0002-0091-6102)
- Craig H. Selzman (ORCID: https://orcid.org/0000-0001-9218-4764)
- Hua Zhu (ORCID: https://orcid.org/0000-0001-7136-7326)
- Ahlke Heydemann (ORCID: https://orcid.org/0000-0002-2626-3787)
- Kenneth C Bedi (ORCID: https://orcid.org/0000-0003-3588-9324)
- Azariyas A. Challa (ORCID: https://orcid.org/0000-0001-7067-1692)
- Stavros G. Drakos (ORCID: https://orcid.org/0000-0002-1223-327X)
- Amy Webb (ORCID: https://orcid.org/0000-0001-5503-7300)
- Andrew N. Carley (ORCID: https://orcid.org/0000-0002-4348-2770)
- Christos P. Kyriakopoulos (ORCID: https://orcid.org/0000-0001-9415-1245)
- Thomas M. Vondriska (ORCID: https://orcid.org/0009-0000-5238-1245)
- E. Douglas Lewandowski (ORCID: https://orcid.org/0000-0002-8970-9491)
- Tatiana Gromova (ORCID: https://orcid.org/0000-0001-5597-2067)
- Zhentao Zhang (ORCID: https://orcid.org/0000-0002-9439-5028)
Institutions
- University of California, Los Angeles (US)
- University of Utah (US)
- University of Illinois Chicago (US)
- Lung Institute (US)
- Anna Needs Neuroblastoma Answers (US)
- Utah Department of Health (US)
- Translational Therapeutics (United States) (US)
- Norwegian Womens Public Health Association (NO)
- University of Utah Health Care (US)
- The Ohio State University (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1161/circresaha.125.327403
- Citations
- 1
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.39