CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer

The effects of CPT1a in the heart extend beyond fatty acid oxidation including noncanonical regulation of gene programs. CPT1a upregulation occurs in nonischemic cardiomyopathy and is a critical cardioprotective adaptation to pathological stress.

Authors

Institutions

Publication Details

Journal
Circulation Research
Published
2025-12-04
DOI
https://doi.org/10.1161/circresaha.125.327403
Citations
1
Primary Topic
Cardiovascular Function and Risk Factors
Type
article
Field-Weighted Citation Impact
1.39
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer

Kenneth B. Margulies, Chandan K. Maurya, Yang Wang, S. Maurya et al.
1 citations
Circulation Research
Cardiovascular Function and Risk Factors
1.39
article

CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer

Kenneth B. Margulies, Chandan K. Maurya, Yang Wang, S. Maurya, Craig H. Selzman, Hua Zhu, Ahlke Heydemann, Kenneth C Bedi, Azariyas A. Challa, Stavros G. Drakos, Amy Webb, Andrew N. Carley, Christos P. Kyriakopoulos, Thomas M. Vondriska, E. Douglas Lewandowski, Tatiana Gromova, Zhentao Zhang
article en
1 citations

Abstract

The effects of CPT1a in the heart extend beyond fatty acid oxidation including noncanonical regulation of gene programs. CPT1a upregulation occurs in nonischemic cardiomyopathy and is a critical cardioprotective adaptation to pathological stress.

Circulation ResearchVol. 138(2)
University of California, Los Angeles (US), University of Utah (US), University of Illinois Chicago (US), Lung Institute (US), Anna Needs Neuroblastoma Answers (US), Utah Department of Health (US), Translational Therapeutics (United States) (US), Norwegian Womens Public Health Association (NO), University of Utah Health Care (US), The Ohio State University (US)
Openalex Percentile: Top 13%
Cardiovascular Function and Risk Factors
1.39
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.