Safety, Utility, and Outcomes of Procainamide Challenge for the Diagnosis and Exclusion of Brugada Syndrome
Procainamide infusion is extremely safe for the diagnosis and exclusion of Brugada syndrome, with yield dependent on pretest probability and indication for testing. Estimated sensitivity and specificity appear to be high. Patients with an asymptomatic procainamide-induced type 1 Brugada pattern are at very low risk of malignant ventricular arrhythmias.
Authors
- Colette Seifer (ORCID: https://orcid.org/0000-0001-9841-7960)
- Simon P. Hansom (ORCID: https://orcid.org/0000-0003-2767-6433)
- Jason D. Roberts (ORCID: https://orcid.org/0000-0003-0268-6723)
- Martin S. Green (ORCID: https://orcid.org/0000-0001-5486-9084)
- Douglas Chan (ORCID: https://orcid.org/0000-0003-0052-3357)
- Andrew D. Krahn (ORCID: https://orcid.org/0000-0002-7982-1586)
- Jeff S. Healey (ORCID: https://orcid.org/0000-0003-1216-7580)
- Rafik Tadros (ORCID: https://orcid.org/0000-0002-1472-0258)
- Vijay S. Chauhan (ORCID: https://orcid.org/0000-0001-9264-5073)
- Bhavanesh Makanjee
- Paul Angaran (ORCID: https://orcid.org/0000-0003-2697-173X)
- Shubhayan Sanatani (ORCID: https://orcid.org/0000-0001-9296-7400)
- Brianna Davies (ORCID: https://orcid.org/0000-0001-9469-7109)
- Ciorsti MacIntyre (ORCID: https://orcid.org/0000-0001-5362-7817)
- Laura Arbour (ORCID: https://orcid.org/0000-0002-9589-0880)
- Habib Khan (ORCID: https://orcid.org/0000-0002-4828-5768)
- Zachary Laksman (ORCID: https://orcid.org/0000-0002-7790-541X)
- Julia Cadrin‐Tourigny (ORCID: https://orcid.org/0000-0002-7489-8744)
- Jacqueline E. Joza (ORCID: https://orcid.org/0000-0003-0956-688X)
- Christian Steinberg (ORCID: https://orcid.org/0000-0003-4112-0028)
- Christopher S. Simpson (ORCID: https://orcid.org/0000-0003-2411-219X)
- Joseph Atallah (ORCID: https://orcid.org/0000-0001-8763-2067)
- Alexios Hadjis (ORCID: https://orcid.org/0000-0003-3094-1648)
- Benjamin M. Moore (ORCID: https://orcid.org/0000-0003-3645-0890)
- David C. Lee (ORCID: https://orcid.org/0000-0001-6857-624X)
- Anne Fournier (ORCID: https://orcid.org/0000-0002-2592-3202)
- Erkan İlhan (ORCID: https://orcid.org/0000-0002-8725-3814)
Institutions
- Western University (CA)
- St. Michael's Hospital (CA)
- Capital District Health Authority (CA)
- University of British Columbia (CA)
- University of Ottawa (CA)
- University of Alberta (CA)
- Queen's University (CA)
- Scarborough Health Network (CA)
- Montreal Heart Institute (CA)
- Royal Jubilee Hospital (CA)
- McGill University Health Centre (CA)
- Toronto General Hospital (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Population Health Research Institute (CA)
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Hôpital du Sacré-Cœur de Montréal (CA)
- BC Children's Hospital (CA)
- University of Manitoba (CA)
- Libin Cardiovascular Institute of Alberta (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Circulation
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1161/circulationaha.125.076011
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00