Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary Hypertension

Hypoxia-induced ADAR1 deficiency upregulates <i>NOCT</i> expression to induce PAEC interferon signaling activation, PAEC apoptosis, and PH. This study provides impetus to target the ADAR1-NOCT axis for more effective diagnostics and therapeutics for PH.

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Publication Details

Journal
Circulation Research
Published
2025-12-04
DOI
https://doi.org/10.1161/circresaha.125.326277
Citations
3
Primary Topic
RNA regulation and disease
Type
article
Field-Weighted Citation Impact
2.42
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article

Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary Hypertension

Yunhye Kim, Chen-Shan Chen Woodcock, Thomas Bertero, Stephen Y. Chan et al.
3 citations
Circulation Research
RNA regulation and disease
2.42
article

Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary Hypertension

Yunhye Kim, Chen-Shan Chen Woodcock, Thomas Bertero, Stephen Y. Chan, Robert Lafyatis, Elena A. Goncharova, Satoshi Okawa, Tim Lahm, Andrea L. Frump, Soni Savai Pullamsetti, John Sembrat, Yassmin Al Aaraj, Mehdi syed Nouraie, Shu‐Ting Cho, Rajan Saggar, Alexandra L. McCubbrey, Yi‐Yin Tai, Tatiana V. Kudryashova, Giovanni Maroli, Bing Wang, Ying Tang, Ke Yuan, Qingde Wang, Hyunbum Kim, Qin Li, Siyi Jiang, Caroline Chauvet, Rami Homsi
article en
3 citations

Abstract

Hypoxia-induced ADAR1 deficiency upregulates <i>NOCT</i> expression to induce PAEC interferon signaling activation, PAEC apoptosis, and PH. This study provides impetus to target the ADAR1-NOCT axis for more effective diagnostics and therapeutics for PH.

Circulation ResearchVol. 138(1)
University of Colorado Hospital (US), Boston Children's Hospital (US), Centre National de la Recherche Scientifique (FR), University of California, Los Angeles (US), University of Pittsburgh (US), National Jewish Health (US), Max Planck Institute for Heart and Lung Research (DE), Pulmonary and Allergy Associates (US), Universities of Giessen and Marburg Lung Center (DE), University of Pittsburgh Medical Center (US), Center for Vascular Biology Research (US), Cardio-Pulmonary Institute (DE), Rocky Mountain MS Center (US), McGowan Institute for Regenerative Medicine (US), Institut de Pharmacologie Moléculaire et Cellulaire (FR), University of Colorado Anschutz Medical Campus (US), Indiana University – Purdue University Indianapolis (US), University of Pennsylvania (US), University of California, Davis (US), University of Colorado Denver (US)
Openalex Percentile: Top 10%
RNA regulation and disease
2.42
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