Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary Hypertension
Hypoxia-induced ADAR1 deficiency upregulates <i>NOCT</i> expression to induce PAEC interferon signaling activation, PAEC apoptosis, and PH. This study provides impetus to target the ADAR1-NOCT axis for more effective diagnostics and therapeutics for PH.
Authors
- Yunhye Kim (ORCID: https://orcid.org/0009-0002-1804-571X)
- Chen-Shan Chen Woodcock (ORCID: https://orcid.org/0000-0003-4291-1788)
- Thomas Bertero (ORCID: https://orcid.org/0000-0002-4801-9902)
- Stephen Y. Chan (ORCID: https://orcid.org/0000-0002-9520-7527)
- Robert Lafyatis (ORCID: https://orcid.org/0000-0002-9398-5034)
- Elena A. Goncharova (ORCID: https://orcid.org/0000-0001-7118-6752)
- Satoshi Okawa (ORCID: https://orcid.org/0000-0003-3916-3109)
- Tim Lahm (ORCID: https://orcid.org/0000-0003-0007-6606)
- Andrea L. Frump (ORCID: https://orcid.org/0000-0002-5972-5079)
- Soni Savai Pullamsetti (ORCID: https://orcid.org/0000-0003-0440-8831)
- John Sembrat (ORCID: https://orcid.org/0000-0003-4108-803X)
- Yassmin Al Aaraj
- Mehdi syed Nouraie (ORCID: https://orcid.org/0000-0001-7465-0581)
- Shu‐Ting Cho (ORCID: https://orcid.org/0000-0003-2140-5165)
- Rajan Saggar (ORCID: https://orcid.org/0000-0002-5536-5934)
- Alexandra L. McCubbrey (ORCID: https://orcid.org/0000-0002-2049-9609)
- Yi‐Yin Tai (ORCID: https://orcid.org/0000-0003-3674-0783)
- Tatiana V. Kudryashova (ORCID: https://orcid.org/0000-0002-2843-5554)
- Giovanni Maroli (ORCID: https://orcid.org/0000-0001-8245-5348)
- Bing Wang (ORCID: https://orcid.org/0000-0002-5185-3500)
- Ying Tang (ORCID: https://orcid.org/0000-0002-2532-3477)
- Ke Yuan (ORCID: https://orcid.org/0000-0001-8085-5452)
- Qingde Wang (ORCID: https://orcid.org/0000-0002-2482-7972)
- Hyunbum Kim (ORCID: https://orcid.org/0000-0002-7193-0278)
- Qin Li (ORCID: https://orcid.org/0000-0002-8948-2717)
- Siyi Jiang (ORCID: https://orcid.org/0000-0002-5481-2771)
- Caroline Chauvet
- Rami Homsi
Institutions
- University of Colorado Hospital (US)
- Boston Children's Hospital (US)
- Centre National de la Recherche Scientifique (FR)
- University of California, Los Angeles (US)
- University of Pittsburgh (US)
- National Jewish Health (US)
- Max Planck Institute for Heart and Lung Research (DE)
- Pulmonary and Allergy Associates (US)
- Universities of Giessen and Marburg Lung Center (DE)
- University of Pittsburgh Medical Center (US)
- Center for Vascular Biology Research (US)
- Cardio-Pulmonary Institute (DE)
- Rocky Mountain MS Center (US)
- McGowan Institute for Regenerative Medicine (US)
- Institut de Pharmacologie Moléculaire et Cellulaire (FR)
- University of Colorado Anschutz Medical Campus (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1161/circresaha.125.326277
- Citations
- 3
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42