L-Type Ca <sub>v</sub> 1.3 and HCN Channels Mediate Heart Rate Acceleration by Catecholamines
PKA phosphorylation of Rad, which disinhibits Ca<sub>v</sub>1.3 channels and cAMP-dependent activation of HCN channels, are key effectors in β-adrenergic regulation of cardiac pacemaker activity and can sustain positive chronotropic effects independently. These findings on Rad-mediated regulation of Ca<sub>v</sub>1.3 and HCN channels unravel the ionic mechanisms underlying the catecholaminergic acceleration of the heart rate.
Authors
- Isabelle Bidaud (ORCID: https://orcid.org/0000-0002-1812-1447)
- Alicia D’Souza (ORCID: https://orcid.org/0000-0002-9700-5523)
- Andrea Saponaro (ORCID: https://orcid.org/0000-0001-5035-5174)
- Walma Pereira de Vasconcelos (ORCID: https://orcid.org/0009-0000-2471-8445)
- Bi-Xing Chen
- Dirk Isbrandt (ORCID: https://orcid.org/0000-0002-4720-1016)
- Mélanie Faure
- Matteo E. Mangoni (ORCID: https://orcid.org/0000-0002-8892-3373)
- Andrew R. Marks (ORCID: https://orcid.org/0000-0002-8057-1502)
- Steve Reiken (ORCID: https://orcid.org/0000-0002-5807-3574)
- Leïla Talssi
- Sihame Laarioui (ORCID: https://orcid.org/0009-0009-4852-371X)
- Eleonora Torre (ORCID: https://orcid.org/0000-0003-1822-8495)
- Matthias Baudot (ORCID: https://orcid.org/0000-0002-8725-3048)
- Anna Moroni (ORCID: https://orcid.org/0000-0002-1860-406X)
- Steven O. Marx (ORCID: https://orcid.org/0000-0002-0577-6030)
- Birgit Engeland (ORCID: https://orcid.org/0000-0001-9104-7194)
- Pietro Mesirca (ORCID: https://orcid.org/0000-0002-9538-3096)
- Marvin Gaillardon
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of Milan (IT)
- Columbia University Irving Medical Center (US)
- German Center for Neurodegenerative Diseases (DE)
- University of Manchester (GB)
- Lung Institute (US)
- University Hospital Cologne (DE)
- Laboratoire d'Excellence Canaux Ioniques d'Intérêt Thérapeutique (FR)
- Institut de Génomique Fonctionnelle (FR)
- Columbia University (US)
- Manchester University (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1161/circresaha.125.327497
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39