Value of 24- to 48-Hour Infarct Volume as a Surrogate for Clinical Outcome in Late-Window Thrombectomy May Be Limited: A Post Hoc Analysis of the AURORA Collaboration
FIV mediated only a small proportion of the EVT effect on clinical outcome, and the association of FIV and outcomes was much weaker; overall outcomes were worse in the control arm compared with the EVT arm. For FIV up to 100 mL, EVT results in substantially better clinical outcomes than best medical management given the same FIV. The utility of FIV as a surrogate outcome in late time-window stroke may be limited.
Authors
- Maarten G. Lansberg (ORCID: https://orcid.org/0000-0002-3545-6927)
- Jeremy Josef Heit (ORCID: https://orcid.org/0000-0003-1055-8000)
- Xabier Urra (ORCID: https://orcid.org/0000-0002-4763-5252)
- Fabrício Oliveira Lima (ORCID: https://orcid.org/0000-0002-0383-4145)
- Tudor G. Jovin (ORCID: https://orcid.org/0000-0002-2619-6975)
- Aquilla S Turk (ORCID: https://orcid.org/0000-0001-8375-0410)
- Andrew M. Demchuk (ORCID: https://orcid.org/0000-0002-4930-7789)
- David S. Liebeskind (ORCID: https://orcid.org/0000-0002-5109-8736)
- Johanna Maria Ospel (ORCID: https://orcid.org/0000-0003-0029-6764)
- Gregory W. Albers (ORCID: https://orcid.org/0000-0003-0263-4632)
- Vincent Costalat (ORCID: https://orcid.org/0000-0001-8428-9101)
- Stephanie Kemp (ORCID: https://orcid.org/0000-0002-2804-6495)
- Sheila Cristina Ouriques Martins (ORCID: https://orcid.org/0000-0002-8452-712X)
- J Mocco (ORCID: https://orcid.org/0000-0001-5489-2524)
- Adnan H. Siddiqui (ORCID: https://orcid.org/0000-0002-9519-0059)
- Ashutosh P. Jadhav (ORCID: https://orcid.org/0000-0002-9454-0678)
- Michael P. Marks (ORCID: https://orcid.org/0000-0002-8610-8623)
- Raul G. Nogueira (ORCID: https://orcid.org/0000-0003-4532-153X)
- Marc Ribó (ORCID: https://orcid.org/0000-0001-9242-043X)
- Diogo C Haussen (ORCID: https://orcid.org/0000-0003-1884-2196)
- Mayank Goyal (ORCID: https://orcid.org/0000-0001-9060-2109)
- Michael D. Hill (ORCID: https://orcid.org/0000-0002-6269-1543)
- Letícia Costa Rebello (ORCID: https://orcid.org/0000-0002-7254-6710)
- Santiago Ortega-Gutierrez
- Scott Brown
- R Budzik
Institutions
- Prisma Health (US)
- Universidade Federal do Rio Grande do Sul (BR)
- Grady Memorial Hospital (US)
- Barrow Neurological Institute (US)
- University of California, Los Angeles (US)
- University of Calgary (CA)
- Vall d'Hebron Hospital Universitari (ES)
- Stanford Medicine (US)
- Cooper University Health Care (US)
- HealthPartners (US)
- Stanford University (US)
Publication Details
- Journal
- Stroke
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1161/strokeaha.125.052109
- Citations
- 1
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35