Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection
People with well-controlled HBV/HIV co-infection maintain robust CD8<sup>+</sup> T cell responses with preserved stem-like properties supporting antiviral function. These results challenge assumptions about additive immune dysfunction in dual chronic infections and highlight the need for tailored immune-modulatory therapies.
Authors
- Kelly da Costa (ORCID: https://orcid.org/0000-0001-6352-3843)
- Anucha Preechanukul (ORCID: https://orcid.org/0000-0001-7428-0058)
- Sanjay R. Bhagani (ORCID: https://orcid.org/0000-0003-2557-4337)
- Patrick T.F. Kennedy (ORCID: https://orcid.org/0000-0001-9201-0094)
- Aljawharah Alrubayyi (ORCID: https://orcid.org/0000-0001-7538-9434)
- Fiona M. Burns (ORCID: https://orcid.org/0000-0002-9105-2441)
- Natasha Fisher-Pearson
- Noshin Hussain (ORCID: https://orcid.org/0000-0001-9363-8174)
- Rachael Bashford-Rogers (ORCID: https://orcid.org/0000-0002-6838-0711)
- Stephanie Kucykowicz (ORCID: https://orcid.org/0000-0002-8849-218X)
- Edward Arbe-Barnes
- Upkar S. Gill (ORCID: https://orcid.org/0000-0001-6146-9708)
- Bo Sun (ORCID: https://orcid.org/0000-0002-5507-6657)
- Dimitra Peppa (ORCID: https://orcid.org/0000-0002-9281-5471)
- Pedro Simoes
- Indrajit Ghosh (ORCID: https://orcid.org/0000-0002-1341-0258)
- Mala K. Maini (ORCID: https://orcid.org/0000-0001-6384-1462)
- Jonida Kokiçi (ORCID: https://orcid.org/0009-0000-3773-492X)
- Sabine Kinloch
- Frances Gorou
- Sarun Prasitdumrong
Institutions
- Queen Mary University of London (GB)
- Royal Free London NHS Foundation Trust (GB)
- Central and North West London NHS Foundation Trust (GB)
- University of Oxford (GB)
- University College London (GB)
Publication Details
- Journal
- Gut
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1136/gutjnl-2025-335461
- Citations
- 1
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35