Astragaloside IV attenuates uremia-induced myocardial injury by inhibiting autophagy via ATF4
AS-IV ameliorated uremia-associated myocardial injury by suppressing ATF4 expression and regulating cardiomyocyte autophagy. The PI3K pathway may modulate autophagy after treatment with AS-IV.
Authors
- Qiudi Tu
- Jianguang Gong (ORCID: https://orcid.org/0000-0001-8690-9669)
- Jihao Xu (ORCID: https://orcid.org/0000-0003-0641-6931)
- Xianyun Ye
- Li Zhao (ORCID: https://orcid.org/0000-0002-2578-9533)
- Jiao Zheng (ORCID: https://orcid.org/0000-0003-4294-9487)
- Bin Zhu (ORCID: https://orcid.org/0000-0003-0249-4254)
Institutions
- Hangzhou Normal University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1038/s41598-025-30374-x
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhejiang Traditional Chinese Medicine Administration