Lactylation-driven KRT19 promotes non-small cell lung cancer progression by suppressing cellular senescence
Our study emphasizes the importance of lactylation-driven KRT19 for overriding senescence and promoting NSCLC progression, reinforcing the potential of combination therapy strategies with KRT19 inhibitors to yield favorable responses in patients with NSCLC.
Authors
- Zihan Gao (ORCID: https://orcid.org/0000-0002-7523-099X)
- Yan‐Lai Tang (ORCID: https://orcid.org/0000-0002-2649-5270)
- Jingyao Lian (ORCID: https://orcid.org/0000-0002-0597-2939)
- Huiping Xu (ORCID: https://orcid.org/0000-0002-4025-6401)
- Xiaoxiao Ye (ORCID: https://orcid.org/0000-0001-6898-5879)
- Yangyang Ji (ORCID: https://orcid.org/0000-0002-2429-1426)
- Haonan Zhou (ORCID: https://orcid.org/0000-0003-2056-6514)
- Yue Du (ORCID: https://orcid.org/0000-0002-9855-011X)
- Cai Zhang
- Fan Yanhong
- Lu Zheng (ORCID: https://orcid.org/0000-0002-7311-5808)
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1186/s13046-025-03602-5
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 1.16