Copper-Catalyzed Asymmetric Allyl Addition of Imines with Allenylsilanes
A copper-catalyzed allylation of N-<i>tert</i>-butanesulfinyl imines with silylallenes has been developed, affording chiral homoallylic amines bearing multiple stereocenters with excellent stereocontrol. The protocol features mild conditions, broad substrate scope, and robustness on a gram scale. Importantly, the allylsilane motif provides a versatile handle for downstream derivatizations. This strategy offers a practical and stereoselective approach to valuable homoallylic amines, highlighting its potential utility in asymmetric synthesis.
Authors
- Shang Gao (ORCID: https://orcid.org/0000-0001-8166-5503)
- Aijun Lin (ORCID: https://orcid.org/0000-0001-5786-4537)
- Menghua Xu
- Zhenhua Gu (ORCID: https://orcid.org/0000-0001-8168-2012)
- Hui Miao (ORCID: https://orcid.org/0000-0001-7451-1311)
- Peng Sun (ORCID: https://orcid.org/0000-0003-0348-5405)
- Chi Yang (ORCID: https://orcid.org/0000-0002-3436-8554)
Institutions
- Fuyang Normal University (CN)
- China Pharmaceutical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China Academy of Chinese Medical Sciences (CN)
- Ministry of Industry and Information Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1021/acs.orglett.5c04532
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00