Application of Cognitive Rehabilitation Strategies in Patients with Brain Tumor-Related Cognitive Impairment

The incidence of brain tumors is increasing annually, and brain tumor-related cognitive impairment has become a critical issue affecting patients' quality of life and long-term prognosis.The mechanisms underlying brain tumor-related cognitive dysfunction are complex, involving multiple factors such as the direct effects of the tumor, treatment-related neurotoxicity, and individual susceptibility. These impairments often manifest across multiple cognitive domains, including memory, attention, executive function, processing speed, and language abilities. As a non-pharmacological intervention based on the principles of neuroplasticity, cognitive rehabilitation through cognitive retraining and functional compensation strategies to demonstrate significant potential in improving cognitive function in patients with brain tumors.This systematic review elaborates on the influencing factors and clinical characteristics of cognitive impairment associated with brain tumors, focusing on the application of cognitive rehabilitation strategies, including computerized cognitive training, goal management training, virtual reality technology, and functional compensation strategies, in core cognitive domains such as attention, memory, language, executive function, and processing speed. However, existing studies are generally constrained by small sample sizes, high heterogeneity in intervention protocols, lack of long-term follow-up, and scarcity of high-quality evidence-based medical evidence. In the future, we should aim to provide a theoretical reference for clinical practice and emphasizes the necessity for future large-scale, multicenter randomized controlled trials, integrated with multimodal neuroimaging assessments, to establish a standardized and individualized cognitive rehabilitation system that is deeply integrated with digital therapeutics, thereby improving the long-term neurocognitive prognosis and quality of life for patients with brain tumors.