SYSTOLIC-DIASTOLIC DISORDERS AND THEIR CORRECTION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

The aim of the study. To evaluate the e—ect of glucose-lowering therapy regimens on the parameters of systolic and diastolic function of the left ventricle in type 2 diabetes mellitus (DM 2). Material and methods. The study included 79 patients with DM 2 and chronic heart failure. Patients were randomized into 4 comparable groups. Cardiac parameters were assessed at baseline, after 3 and 12 months. Results. During 3 months of treatment, there were no changes in systolic parameters. After 12 months, in groups 1 and 2, an increase in the end-systolic size was noted, in group 3 its value did not change, and in group 4, a downward trend appeared. The end-systolic volume increased in groups 1, 2, and 3, while there were no changes in group 4. The ejection fraction and isovolumic relaxation time decreased in groups 1-3 and did not change in group 4. The left atrium increased in size after 12 months in groups 1, 2, and 3, while in group 4, on the contrary, it regressed from 4.6±0.04 to 4.3±0.01 cm. The end-diastolic size and end-diastolic volume increased in groups 1, 2, and 3, while they did not change in group 4. The E peak decreased in all groups, while in group 4 it increased from 75.2±2.2 to 79.3±1.5 cm/s. The A peak did not change in groups 1, 2, and 3, while in group 4 it decreased from 77.5±1.7 to 75.4±0.8 cm/s. The isovolumic relaxation time increased in group 1, while it decreased in groups 2, 3, and 4. The early diastolic †lling deceleration time increased in groups 1, 2, and 3, while it decreased in group 4. Conclusions. The combination of sodium glucose cotransporter 2 inhibitors with metformin has a bene†cial e—ect on ventricular systolic-diastolic parameters.