Bilateral Deep Brain Stimulation of the Subthalamic Nucleus or Globus Pallidus Internus Improves Gait Impairment in Parkinson's Disease
Bilateral STN or GPi DBS should be considered for treatment of gait as both targets improved gait kinematics acutely and chronically. Acute effects of STN or GPi DBS on gait speed should be considered when programming patients as they predict chronic effects. When determining DBS candidacy, the levodopa response on the MDS-UPDRS axial subscore should be considered. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Christine D. Esper (ORCID: https://orcid.org/0000-0002-1093-6537)
- Julie Tran (ORCID: https://orcid.org/0000-0001-6520-2832)
- Faiçal Isbaine (ORCID: https://orcid.org/0000-0002-4159-420X)
- Lenora Higginbotham (ORCID: https://orcid.org/0000-0002-8694-9211)
- Pratibha Aia
- Paola Testini (ORCID: https://orcid.org/0000-0002-3024-5557)
- Laura Scorr (ORCID: https://orcid.org/0000-0002-4569-6393)
- Jamal Al Ali (ORCID: https://orcid.org/0000-0001-6301-9903)
- J. Lucas McKay (ORCID: https://orcid.org/0000-0002-8361-8943)
- Joe R. Nocera (ORCID: https://orcid.org/0000-0002-3338-9927)
- Cathrin M. Buetefisch (ORCID: https://orcid.org/0000-0001-6473-7800)
- Svjetlana Miocinovic (ORCID: https://orcid.org/0000-0001-9237-0276)
- Nicholas Au Yong (ORCID: https://orcid.org/0000-0002-7898-7832)
- Shirley Triche
- Richa Tripathi (ORCID: https://orcid.org/0000-0001-8228-9052)
Institutions
- Emory University (US)
- University of Utah (US)
- Atlanta VA Health Care System (US)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1002/mds.70146
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Michael J. Fox Foundation for Parkinson's Research
- American Parkinson Disease Association
- Office of Research and Development
- Emory University
- Parkinson Study Group
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Institute of Neurological Disorders and Stroke